Two New Drugs Promise Long Longer Healthier Living

https://i0.wp.com/deutsche-boerse.com/dbag/dispatch/en/binary/gdb_content_pool/imported_files/public_files/20_images/73_is_overview_slides/82_282x180/mda_xpect_282x180.jpg“The new drugs are called sirtuin activators, meaning that they activate an enzyme called sirtuin. The basic theory is that all or most species have an ancient strategy for riding out famines: switch resources from reproduction to tissue maintenance. A healthy diet but with 30 percent fewer calories than usual triggers this reaction in mice and is the one intervention that reliably increases their life span.

But most people cannot keep to a diet with a 30 percent cut in calories, so a drug that could activate the famine reflex might be highly desirable. Dr. Leonard Guarente, an M.I.T. biologist who founded the field of sirtuin biology, thinks the famine reflex is mediated through the sirtuin enzymes. Dr. Sinclair, his former student, discovered that sirtuins could be activated by drugs. The most potent activator that emerged from his screens was resveratrol, a natural substance found in red wine, though in amounts probably too low to be significant for health.

“The Sirtris drug being tested in diabetic patients is a special formulation of resveratrol that delivers a bloodstream dose five times as high as the chemical alone. This drug, called SRT501, has passed safety tests and, at least in small-scale trials, has reduced the patients’ glucose levels.

The other drug is a small synthetic chemical that is a thousand times as potent as resveratrol in activating sirtuin and can be given at a much smaller dose. Safety tests in people have just started, with no adverse effects so far….resveratrol has doubled muscular endurance, lowered the bad form of cholesterol, protected against various bad effects of a high-fat diet and suppressed colon cancer. New reports are confirming some of these benefits, but others are ambiguous or puzzling. “…. <More>

Advertisements

4 Comments

Filed under Bannaga, Beyond 5G, Innovation, Science, Smart Living, Social Issues

4 responses to “Two New Drugs Promise Long Longer Healthier Living

  1. Dr. Fielding

    Since the original Dr. Sinclair study was published in Nature a flood of dubious companies have sprung up selling resveratrol. Consumer Lab, the independent authority on supplement quality and safety, evaluated the major brands and found many to be deficient in terms quality and quantity.

    The highest potency products that passed their evaluation were Biotivia, Transmax and Bioforte. Biotivia.com transmax is also the one used in many of the published studies. A product by Life Extension Foundation failed badly with only 26% of the claimed resveratrol. Another brand, Revatrol, had virtually no resveratrol in its supplement. Several other products that passed on quality, such as Longevinex, had so little resveratrol in their products that the cost per mg was sky high. Most of the newer online suppliers declined to have their products tested. The Consumer Lab test results are available on their web site at http://www.consumerlab.com.

  2. The highest potency products that passed their evaluation were Biotivia, Transmax and Bioforte. Biotivia.com transmax is also the one used in many of the published studies. A product by Life Extension Foundation failed badly with only 26% of the claimed resveratrol. Another brand, Revatrol, had virtually no resveratrol in its supplement.

  3. Pingback: Thinner and Healthier with a Pill-Part 2 « Bannaga

  4. These studies were conducted on laboratory animals and believed to have similar benefits on humans. The only real proof is from personal testimonials of people taking Resveratrol Supplements .

    These types of Anti Aging Supplements will only be proven many years from now when people are living to be 120. Doctors are comfortable that taking Resveratrol now will slow down the aging process and prolong life expectancy.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s